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目的 研究精氨酸 天冬氨酸 (Arg Asp ,RD)抗涎腺腺样囊性癌实验性肺转移 (salivaryadenoidcysticcarcinomalungmetastation ,SACC LM)的作用。方法 观察不同剂量、不同时间RD灌胃对SACC LM的影响。结果 30mg/kg和 12 0mg/kgRD灌胃可抑制SACC LM的形成 ;7 5mg/kg、30mg/kg、12 0mg/kgRD灌胃均可延长SACC LM鼠的生存期。结论 RD毒性小 ,可经口给药 ,具有抗SACC LM的作用。
Objective To study the effect of Arg Asp (RD) against salivary adenoid cystic carcinoma lung metastasis (SACC LM). Methods Different doses of RD at different times on the impact of SACC LM. Results The intragastric administration of 30 mg / kg and 120 mg / kg of RD could inhibit the formation of SACC LM. The survival of SACC LM rats was prolonged by 75 mg / kg, 30 mg / kg and 120 mg / kg of RD. Conclusion RD toxicity is small, oral administration, with anti-SACC LM role.