[目的 ]研究甲型肝炎减毒活疫苗 (L A 1)猴体安全性及免疫原性。 [方法 ]对 10年来生产的甲型肝炎减毒活疫苗的猴体试验结果作回顾性分析 ,每年选取 1批制品 ,于当年接种 5只恒河猴 ,于 0、4、8周肝穿做肝组织病理检查及ALT检测 ,并于 0、2、4、8周采血测定 抗HAV阳转情况。 [结果 ]恒河猴接种甲肝疫苗后肝组织病理未见异常 ;8周时抗 HAV10 0 %阳转。 [结论 ]甲型肝炎减毒活疫苗具有良好的安全性和免疫原性 [Objective] To study the safety and immunogenicity of monkeys with live attenuated hepatitis A vaccine (L A 1). [Method] The results of monkeys experiment of live attenuated Hepatitis A vaccine produced in 10 years were retrospectively analyzed. One batch of products was selected each year and 5 rhesus monkeys were inoculated in the same year. Liver histopathological examination and ALT detection, and at 0, 2, 4, 8 weeks blood determination of anti-HAV positive rotation. [Results] The pathology of liver tissue of rhesus monkeys inoculated with hepatitis A vaccine showed no abnormality. At 8 weeks, anti-HAV10 0% was positive. [Conclusion] The live attenuated hepatitis A vaccine has good safety and immunogenicity