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1,25—二羟基胆钙化醇(1,25—(OH)_2D_3)的发现,导致了有关维生素D及其代谢物研究的迅速发展。这些研究进展,不仅吸引了各个生物学科的广泛兴趣,而且使人们对于维生素D在机体钙平衡调节中的作用方式有了相当深入的了解。但从生物化学的角度看,如有关钙离子的跨膜、跨细胞运输的机制问题,以及有关1,25—(OH)_2D_3在这些过程中的作用等,都仍然是些尚未解决的问题。钙离子在维持多种组织细胞的正常功能上具有
The discovery of 1,25-dihydroxycholecalciferol (1,25- (OH) _2D_3) has led to the rapid development of studies on vitamin D and its metabolites. These advances have not only attracted a great deal of interest in various biological disciplines, but also have gained a deep understanding of the mode of action of vitamin D in the regulation of calcium balance in the body. However, from the biochemical point of view, such as the mechanism of transmembrane and transcellular transport of calcium ions, and the role of 1,25- (OH) _2D_3 in these processes are still some unsolved problems. Calcium ions have the normal function of maintaining a variety of tissue cells