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利用正相高效液相色谱法在一种纤维素衍生物手性固定相(OJ-H或OD-H)上成功分离了一系列α位取代的CF2芳香醇及其酯化后的对映异构体。通过考察流动相组成、流速、进样浓度和温度等因素对对映体分离的影响,优化色谱分离条件。
A series of alpha-substituted CF2 aromatic alcohols and their esterified enantiomers were successfully separated on a cellulose derivative chiral stationary phase (OJ-H or OD-H) using normal-phase high performance liquid chromatography Structure. By investigating the influence of mobile phase composition, flow rate, injection concentration and temperature on enantiomeric separation, the chromatographic conditions were optimized.