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993名HBsAg携带者母亲所生新生儿,以768名新生儿为试验组,226名新生儿为对照组,试验组分别注射HBsAg血源性氢氧化铝佐剂疫苗,乙型肝炎高价免疫球蛋白(HBlg)或疫苗加HBIg,对照组注射安慰剂,所用疫苗为国产81-2、82-1-2、83-1和美国NIHA9,观察表明,出生后六个月,试验组各批疫苗的保护率为60～93％,以83-1批为最高;疫苗加HBIg的保护效果与疫苗相似,HBIg组亦有70％的保护效果,以上结果证明单独应用HBsAg疫苗阻断母婴传播的效果是理想的。
993 newborns born to mothers with HBsAg carriers, 768 newborns as test group and 226 newborn as control group, the experimental group were injected with HBsAg blood-borne aluminum hydroxide adjuvant vaccine, hepatitis B high-price immunoglobulin (HBlg) or vaccine plus HBIg, the control group was injected with placebo, the vaccine used for the domestic 81-2,82-1-2,83-1 and the United States NIHA9, the observation showed that six months after birth, the experimental group vaccine The protection rate was 60-93%, which was the highest in 83-1 batches. The protective effect of vaccine plus HBIg was similar to that of vaccine, and HBIg group also had 70% protective effect. The above results proved that the effect of using HBsAg vaccine alone to block mother-to-child transmission Is ideal.