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目的通过对胎鼠心肌组织基因表达谱的检测,探讨大鼠孕前及孕早期甲醛暴露对胎鼠心肌组织基因表达的影响。方法将性成熟的雌性SD大鼠随机分为实验组(甲醛吸入组)和对照组。甲醛吸入组母鼠在受孕前13 d给予甲醛吸入至怀孕第14天,对照组母鼠不进行甲醛吸入,两组母鼠喂养方式无差异。在SD大鼠怀孕第14天时取出胎鼠,对胎鼠心肌组织进行基因芯片检测分析。结果母鼠甲醛吸入组的胎鼠心肌样本与母鼠未吸入甲醛的胎鼠心肌样本相比,有25种与心脏发育相关基因的表达出现上调,且其上调倍数均大于3倍。结论雌性SD大鼠甲醛暴露对其胎鼠心肌中与心脏发育相关的基因表达有影响,为进一步进行先天性心脏病发病机制的研究提供了依据。
OBJECTIVE: To detect the gene expression profile of fetal rat myocardial tissue and to explore the effect of formaldehyde exposure on gene expression of fetal rat myocardium before and during the first trimester of pregnancy. Methods Sexually mature female SD rats were randomly divided into experimental group (formaldehyde inhalation group) and control group. Formaldehyde inhalation group 13 days before conception, inhalation of formaldehyde inhalation until 14 days of pregnancy, the control group of female rats without formaldehyde inhalation, two groups of female rats was no difference in feeding. Fetal rats were removed on the 14th day of gestation in SD rats, and gene chip detection was performed on fetal rat myocardial tissues. Results Compared with the non-inhaled formaldehyde fetal rat myocardium, the expression levels of 25 genes related to cardiac development were up-regulated in fetal rat cardiac muscle samples of female rats inhaled with formaldehyde and their up-regulated times were all more than 3 times. Conclusion Formaldehyde exposure in female SD rats may affect the gene expression related to cardiac development in fetal rat hearts and provide basis for further study on the pathogenesis of congenital heart disease.