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临床心脏病学中应用最广的4个抗体是:(1)Digibind,抗地高辛多株抗体片段,用于治疗致命性地高辛中毒;(2)OKT_3,抗T细胞单株抗体,作为心脏移植术后的免疫抑制治疗;(3)Myoscint,~(111)铟标记的抗肌凝蛋白单株抗体,用于心肌坏死时的显象;(4)7E_3,抗血小板抗体,抑制血小板功能。这些抗体是基因重组技术制成的一些蛋白。抗地高辛抗体免疫作用抗地高辛抗体能降低细胞外地高辛浓度,促使受体结合部位释放地高辛,从而降低细胞(如红细胞、肾皮质细胞)内地高辛水平。实验证明,抗地高辛抗体能消除
The four most widely used antibodies in clinical cardiology are: (1) Digibind, an anti-digoxin multi-antibody fragment for the treatment of deadly digoxin poisoning; (2) OKT_3, an anti-T cell monoclonal antibody, As an immunosuppressive therapy after heart transplantation; (3) Myoscint, an indium-labeled anti-myosin monoclonal antibody for myocardial necrosis; (4) 7E_3, anti-platelet antibody, Features. These antibodies are made from recombinant proteins. Anti-digoxin antibody immunization Anti-digoxin antibody can reduce the concentration of extracellular digoxin, prompting the release of digoxin binding sites, thus reducing the cells (such as red blood cells, renal cortical cells) digoxin levels. Experiments show that anti-digoxin antibodies can be eliminated