亚硫酸氢钠是一种广泛使用的抗氧剂,已知可与药物分子中各种官能团如醛、酮和烷烃产生可逆或不可逆反应。亚硫酸氢盐可使肾上腺素和其它药物分子失活,也有关于亚硫酸氢盐在尿嘧啶型分子C=C双键上起加成作用以及最近关于亚硫酸氢盐对酯水解的催化作用的报道。已知毒扁豆碱在亚硫酸氢盐存在的溶液中稳定,但早期的研究主要涉及抗氧剂在药物氨基甲酸酯水解速率的催化作用,后来注意到亚硫酸氢钠与毒扁豆碱可迅 Sodium bisulfite is a widely used antioxidant known to produce reversible or irreversible reactions with various functional groups in drug molecules such as aldehydes, ketones and alkanes. Bisulfite inactivates epinephrine and other drug molecules, as well as the additive action of bisulfite on the uracil-type C = C double bond and more recently on the catalytic effect of bisulfite on ester hydrolysis Reported. It is known that physostigmine is stable in the presence of bisulfite, but earlier studies mainly involved the catalysis of antioxidants in the rate of drug carbamate hydrolysis and later noted that sodium bisulfite and physostigmine