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临床发现,口服避孕药的同时如服用具有吸附作用的抗溃疡药可引起月经失调和阴道出血。为此本文研究了某些抗酸药、肠道吸附药及抗溃疡药对复方炔诺酮片(Anovlar 1,每片含醋酸炔诺酮1毫克和炔雌醇0.05毫克)中醋酸炔诺酮体外释放度的影响。实验按Fuchs的方法,将复方炔诺酮片置于0.1M盐酸中,搅拌1小时后,用氯仿提取溶解的醋酸炔诺酮,提取液加硫酸钠振摇,然后通氮气流干燥,所得残渣加异烟肼液显色,用分光光度法于410毫微米波长处于1厘米吸收池中,测定吸收度,同时作一空白。醋酸炔诺酮的释放量即可从在相同条件下绘制的标准曲线中求
Clinical findings, oral contraceptives while taking anti-ulcer drugs with adsorption can cause menstrual disorders and vaginal bleeding. In this paper, we studied the effect of certain antacids, gut absorption and antiulcer drugs on the toxicity of norethisterone acetate in combination with norethindrone acetate (Anovlar 1, each containing 1 mg acetate and ethinyl estradiol 0.05 mg) Effect of in vitro release. Experiment according to Fuchs method, the compound norethisterone tablets were placed in 0.1M hydrochloric acid, stirred for 1 hour, the dissolved norethisterone acetate was extracted with chloroform, the extract was added sodium sulfate shaken, and then dried by nitrogen flow, the resulting residue Add isoniazid liquid color, using spectrophotometry at 410 nm wavelength in a 1 cm absorption cell, measured absorption, while making a blank. Norethindrone acetate release can be obtained from the standard curve drawn under the same conditions