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目的通过对玉林市首例人感染高致病性禽流感病例的流行病学调查分析,寻找发病关联因素,为制定人禽流感防控措施提供科学依据。方法采用流行病学调查,结合临床症状及体征、RT-PCR法进行分析和诊断。结果患者发热,体温39.8℃,白细胞减少,胸片示肺炎征象,两肺病灶进展迅速,因呼吸衰歇死亡,气管吸取物A/H5N1核酸阳性,病毒分离阳性。流行病学调查患者有明确的病禽接触史,28名病例密切接触者经7d医学观察身体均健康。结论该病例是玉林市首次报告的人禽流感病例,需加强禽流感疫情监测,采取积极防治措施,降低发病率和病死率。
Objective To investigate the epidemiological analysis of the first human case of human pathogenic avian influenza in human in Yulin and find out the related factors of morbidity in order to provide a scientific basis for the development of human bird flu prevention and control measures. Methods Epidemiological survey, combined with clinical symptoms and signs, RT-PCR analysis and diagnosis. Results The patient was fever, body temperature 39.8 ℃, leukopenia, chest X-ray showed signs of pneumonia, rapid progression of both lung lesions, death due to respiratory failure, tracheal aspirate A / H5N1 positive nucleic acid positive isolation of the virus. Epidemiological survey of patients with a clear pathogen history of exposure, 28 cases of close contact with the 7d medical observation of the body are healthy. Conclusion This case was the first case of human bird flu reported in Yulin City. It is necessary to strengthen the surveillance of bird flu and take active prevention and control measures to reduce morbidity and mortality.