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目的：犬脑照射后，观察不同时期的反应，病理及CT的变化，为CT诊断放射性脑坏死提供新的依据．方法：用SL75－14型直线加速器对犬脑行外照射，建立犬脑放射性损伤模型．结果：早期病理所见血管周围性水肿，细胞凝固性坏死系射线直接损伤脑组织，脱髓鞘与少突胶质细胞坏死有关，CT显示为低密度区；放射性脑坏死在CT显示为增强效应的包块，坏死区出血和炎细胞浸润是放射性脑坏死的特征，可作为与脑瘤复发的鉴别点．结论：照射侧的脑室扩大是由脑萎缩引起的，而不是颅压升高所致ICT能反映放射性脑损伤的程度．
OBJECTIVE: To observe the changes of response, pathology and CT in different periods after canine brain irradiation and to provide a new basis for CT diagnosis of radioactive brain injury. Methods: The canine brain was exposed to external radiation with a SL75-14 linear accelerator to establish a radioactive injury model of canine brain. Results: Early pathological findings of perivascular edema, cell coagulation necrosis Department of ray damage in brain tissue, demyelination and oligodendrocyte necrosis, CT showed low density area; radioactive brain necrosis in CT showed enhanced effect Of the mass, necrotic hemorrhage and inflammatory cell infiltration is a characteristic of radioactive brain necrosis, can be used as a recurrence of brain tumor identification. CONCLUSIONS: Ventricular enlargement at the irradiation side is caused by brain atrophy, rather than the fact that ICT due to increased intracranial pressure reflects the extent of radiation-induced brain injury.