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采用３月龄♂ＳＤ大鼠１６只，随机分为对照组和羟基脲组，后者每周喂羟基脲三次，３ｍｏｎ后对两组大鼠胫骨中段的骨片用图象分析仪进行测算和分析。羟基脲组和对照组比较；皮质骨面积百分数减少７％（Ｐ＜０．００１）、骨髓腔面积百分数增加２８％（Ｐ＜０．００１）、内骨膜面皮质骨的荧光标记周长百分数增加８０％（Ｐ＜０．０５）、骨矿化沉积率增加３９７％（Ｐ＜０．０５）、骨形成率增加５２９％（Ｐ＜０．０５）、骨吸收周长百分数增加１５６％（Ｐ＜０．０５）。所获参数反映出用羟基脲能建立大鼠骨质疏松模型，并认为在＂阳虚＂状态下会造成骨量丢失。
Sixteen 3-month-old male SD rats were randomly divided into control group and hydroxyurea group. The latter were fed with hydroxyurea three times a week. After 3months, the bone fragments in the middle part of the tibia were measured by image analyzer analysis. The percentage of cortical bone area decreased by 7% (P <0.001), the marrow cavity area increased by 28% (P <0.001), and the percentage of fluorescent marker perimeter increased The bone mineralization rate increased by 397% (P <0.05), the bone formation rate increased by 529% (P <0.05) and the percentage of bone resorption perimeter increased by 156% (P <0.05) <0.05). The obtained parameters reflect the use of hydroxyurea to establish a rat model of osteoporosis, and that in the “Yang” state will cause bone loss.