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硝苯吡啶(Nifedipine)国内商品名心痛定,为血管扩张剂,是目前比较理想的预防和治疗心绞痛的药物。因本品是一种很强的钙离子拮抗剂,除了被广泛应用治疗缺血性心脏病外,近年来国外关于它对成人泌尿道平滑肌的扩张作用做了药理研究及治疗各类尿道梗阻的临床报道。证明硝苯吡啶对尿频、尿痛,排尿不尽感以及轻度尿失禁有较好的疗效。尿道、膀胱和输尿管平滑肌,象其它平滑肌一样,其收缩作用也受细胞内游离钙浓度的支配。硝苯吡啶能选择性地抑制钙离子的浓度。因此,它不仅能松弛心肌,改善心肌的能量平衡;也对泌尿道平滑肌产生扩张作用,治疗尿道梗阻。
Nifedipine (Nifedipine) Domestic trade name nifedipine, vasodilator, is currently the ideal drug for the prevention and treatment of angina pectoris. Because this product is a strong calcium antagonist, in addition to being widely used in the treatment of ischemic heart disease, in recent years abroad on its expansion of adult urinary tract smooth muscle pharmacological research and treatment of various types of urinary tract obstruction Clinical reports. Prove nifedipine on urinary frequency, dysuria, urinary exhaustion and mild urinary incontinence have a good effect. The urethra, bladder, and ureter smooth muscle, like other smooth muscles, are also affected by the intracellular free calcium concentration. Nifedipine selectively inhibits the concentration of calcium ions. Therefore, it not only relaxes the myocardium, improves the energy balance of the myocardium, but also expands the smooth muscle of the urinary tract to treat urethral obstruction.