论文部分内容阅读
应用高效液相色谱－电化学检测法（ＨＰＬＣ－ＥＣＤ）测定大鼠在用绵羊红细胞（ＳＲＢＣ）免疫后第２—７天期间，下丘脑、海马、脑干、胸腺和脾脏中去甲肾上腺素（ＮＡ）含量的变化。实验结果表明，下丘脑内ＮＡ含量在免疫后第４—７天明显增加，其中第７天有回降趋势。海马内ＮＡ含量在第４—５天显著增多。而胸腺和脾脏中ＮＡ水平在第４—５天均明显降低。脑干在免疫应答期间无明显改变。以上结果说明，体液免疫应答可影响脑和淋巴器官中ＮＡ的代谢，结合我们以前的研究结果ＮＡ可影响Ｔ淋巴细胞的增殖反应，说明ＮＡ与免疫系统之间存在着相互作用。
The contents of norepinephrine in hypothalamus, hippocampus, brainstem, thymus and spleen were determined by HPLC-ECD from day 2-7 after immunization with sheep red blood cells (SRBC) (NA) content changes. The experimental results show that the content of NA in the hypothalamus significantly increased from day 4 to day 7 after immunization, with a downward trend on the 7th day. NA content in hippocampus in the first 4-5 days significantly increased. However, NA levels in thymus and spleen decreased significantly on days 4-5. Brainstem did not change significantly during the immune response. The above results indicate that the humoral immune response can affect NA metabolism in the brain and lymphoid organs. In combination with our previous study, NA can affect the proliferative response of T lymphocytes, indicating that there is an interaction between NA and the immune system.