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目的:比较4种选药方案治疗复治后耐多药结核病的治疗疗效。方法:回顾性分析152例复治后耐多药结核病例,按治疗方案分为4组。Ⅰ组采用标准化疗方案HSRZE;Ⅱ组根据过去的治疗史组成个体化方案;Ⅲ组根据药敏试验组成个体化方案;Ⅳ组采用力克肺疾、左氧氟沙星、卷曲霉素、阿奇霉素、阿莫西林克拉维酸方案。结果:4组病灶吸收有效率分别为20.00%、47.37%、52.38%、81.48%;4组12个月疾菌阴转率分别为22.22%、57.89%、50.00%、81.48%。结论:对于所有复治肺结核患者均采用统一的标准复治方案有效率低,由力克肺疾、左氧氟沙星、卷曲霉素、阿奇霉素、阿莫西林克拉维酸联合组成的化疗方案是治疗复治后耐多药结核病的有效方案。
Objective: To compare the efficacy of four kinds of drug regimens in the treatment of multidrug-resistant tuberculosis after retreatment. Methods: A retrospective analysis of 152 cases of multidrug-resistant tuberculosis after retreatment, according to the treatment plan is divided into 4 groups. In group Ⅰ, standard chemotherapy HSRZE was used; in group Ⅱ, individualized plans were made according to the past treatment history; in group Ⅲ, individualized plans were made according to drug susceptibility test; in group Ⅳ, Lectacine, levofloxacin, capreomycin, azithromycin, amoxicillin Vitamin solution. Results: The effective rates of four groups were 20.00%, 47.37%, 52.38% and 81.48%, respectively. The negative conversion rate of the four groups of 12 months was 22.22%, 57.89%, 50.00% and 81.48% respectively. CONCLUSIONS: A standardized standard of regimen for all patients with re-treatment of pulmonary tuberculosis is ineffective. Chemotherapy regimens consisting of Lectra, levofloxacin, capreomycin, azithromycin and amoxicillin-clavulanic acid are used to treat post-remission Multi-drug effective program of tuberculosis.