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获取稳定可靠的帕金森氏病 (PD)模型是进行PD研究的重要环节。 6 OH DA立体定向注射毁损内侧前脑束(MFB)由于安全可靠而成为近年大鼠PD模型制作的常用方法。本研究旨在探讨MFB毁损大鼠PD模型的制作和模型鼠“自发”旋转行为的意义。一、材料和方法1.2 0 0～ 2 2 0 g的雌性SD大
Obtaining a stable and reliable model of Parkinson’s disease (PD) is an important part of PD research. Stereotactic injection of 6 OHDA in the medial forebrain bundle (MFB) has become a common method for making rat PD models in recent years because of its safety and reliability. The purpose of this study is to investigate the preparation of PD model in rats with MFB-damaged and the significance of “spontaneous” rotation in model mice. First, materials and methods 1.2 0 0 ~ 2 2 0 g female SD is large