北京大学医学部Li W等人近期做了一项研究,旨在探讨在初治的急性和慢性HBV感染者肝内cccDNA与血清HBsAg及HBV DNA之间的关系。他们共纳入120名患者,所有患者均进行了肝活组织检查,其中19例急性乙型肝炎,101例慢性HBV感染(其中10例处于免疫耐受期,59例处于免疫清除期,8例处于低复制期,24例为HBe Ag阴性)。分别对入组患者的肝内cccDNA、血清表面抗原和血 A recent study by Li W et al., Peking University Health Science Center, aims to investigate the relationship between intrahepatic cccDNA and serum HBsAg and HBV DNA in newly diagnosed acute and chronic HBV-infected individuals. They enrolled a total of 120 patients, all of whom underwent liver biopsy, of which 19 had acute hepatitis B and 101 had chronic HBV infection (10 in immunocompromised, 59 in immunosuppression and 8 in Low replication, 24 cases of HBe Ag negative). Intrahepatic cccDNA, serum surface antigens and blood were included in the enrolled patients, respectively