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目的 研究乙型脑炎减毒活疫苗对国内外不同野毒株的免疫原性。方法 用小鼠保护力试验和空斑减少中和试验检测该疫苗对国内外不同野毒株攻击的保护作用及其免疫血清的中和能力。结果 小鼠免疫 1针后均能抵抗国内 11株和国外 11株乙脑病毒的攻击 ,保护率均可达 90 %以上 ;人体免疫血清对台湾 1株和国外 9株病毒均有明显的中和作用。结论 SA14 142株乙脑活疫苗具有广谱的免疫原性。
Objective To study the immunogenicity of live attenuated Japanese encephalitis vaccine against different wild strains at home and abroad. Methods The protective effect of different vaccines against domestic and foreign aggression and the neutralization ability of immune serum were tested by mouse protective test and plaque reduction neutralization test. Results After immunization, all the mice were challenged by 11 domestic and 11 foreign JE viruses, with the protection rate reaching more than 90%. The human immune serum showed significant neutralization to 1 strain of Taiwan and 9 foreign strains of virus effect. Conclusion SA14 142 JE vaccine has broad-spectrum immunogenicity.