病例选择标准:(1)皮肤牛奶咖啡色斑的直径在6cm以上,全身可见6块以上者;(2)全身神经纤维瘤20个以上者或经病理证实为此瘤;(3)有牛奶咖啡斑和皮肤神经纤维瘤或与由神经纤维瘤而引起的其他病损者。 本组35例患者中,男21例,女14例。有家族遗传史者21例(占60％),分布在8个家族中。其中,一家有2例发病者4个家族,有3例发病者3个家族,有4例发病者1个家族。有遗传史的7个家族中,父母 Case selection criteria: (1) The diameter of the skin milk coffee stain is more than 6cm, and more than 6 are visible in the whole body; (2) 20 or more of the whole body neurofibromas or the pathological confirmation of this tumor; (3) There is milk coffee Plaque and cutaneous neurofibromatosis or other lesions caused by neurofibromas. Of the 35 patients in this group, 21 were males and 14 were females. There are 21 cases (accounting for 60%) of family history, distributed in 8 families. Among them, one family has 2 cases of 4 families, 3 cases of 3 families, and 4 cases of 1 family. In 7 families with a genetic history, parents