目的　分析影响糖尿病患者多种心血管危险因素集簇现象的因素。方法　调查 6 54例糖尿病患者并发症情况和血糖、胰岛素、HbA1c、胆固醇、甘油三酯、LDL 胆固醇、HDL 胆固醇、体重指数、腰围、臀围以及腰臀围比值等因素 ,采用HOMA公式计算出胰岛素抵抗指数。按照并存心血管危险因素 (高血压、全身性肥胖、中心性肥胖、高胆固醇血症、低HDL 胆固醇血症 )数量 ,进行分析。结果　并有 3种以上的心血管危险因素明显地高于随机的单一因素并存的计算预测值 ,餐后胰岛素水平和胰岛素面积随危险因素的增加而增加。采用有性别差异的全身性肥胖和中心性肥胖的诊断标准 ,女性糖尿病患者有更多的心血管危险因素。如果采用男女性别相同的诊断标准 ,这种并存多种心血管危险因素的性别差异则消失。多数患者的这些危险因素未得到良好的控制。结论　糖尿病多种心血管危险因素集簇是常见的 ,可能与高胰岛素血症及性别有关 Objective To analyze the factors influencing the clustering of cardiovascular risk factors in diabetic patients. Methods The complication of 6 54 diabetic patients and the ratio of blood glucose, insulin, HbA1c, cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, body mass index, waist circumference, hip circumference and waist- hip ratio were investigated. HOMA formula was used to calculate the insulin Resistance index. The analysis was based on the number of concurrent cardiovascular risk factors (hypertension, generalized obesity, central obesity, hypercholesterolemia, low HDL cholesterol). Results There were 3 or more cardiovascular risk factors significantly higher than the random single factor coexistence calculation predictions, postprandial insulin levels and insulin area increased with the risk factors. Adopting gender-based diagnostic criteria for generalized obesity and central obesity, women with diabetes have more cardiovascular risk factors. If gender-based diagnostic criteria are used, the gender gap in multiple cardiovascular risk factors coexists. Most of these risk factors are not well controlled. Conclusions Clusters of various cardiovascular risk factors for diabetes are common and may be related to hyperinsulinemia and gender