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本文总结了最近几年甾体避孕药的研究现状,并给邓予相应的评价。当前甾体避孕药研究的特点是:一方面改进现有避孕药使其更趋完善、安全可靠;另一方面则重视基础理论研究以指导新药的开发。通过降低剂量、改变剂型和投药方式,不少避孕药的新剂型,如多相片、长效针、含药宫内节育器、埋植剂或阴道环等均已取得成效,很有发展前途。新避孕药地索高诺酮优于D-18甲基炔诺酮;研究中抗早孕新药Ru486很有希望,值得给予重视。从拮抗子宫内膜孕酮受体或抑制胎盘孕酮合成的甾体化合物中寻找抗早孕新药乃是今后的重要研究方向。
This article summarizes the current status of the research on steroidal contraceptives in recent years and gives Deng appropriate comments. The current study of steroid contraceptives is characterized by: on the one hand to improve the existing contraceptives to make it more perfect, safe and reliable; the other hand, emphasis on basic theoretical research to guide the development of new drugs. Many new forms of contraceptives such as multiphasics, long-acting needles, drug-containing IUDs, implants or vaginal rings have achieved great success by reducing dosage, changing dosage forms and administration methods. New contraceptives Sorotinone superior to D-18 norgestrel; study of anti-early pregnancy Ru486 promising new drugs, it is worth attention. Looking for new anti-early pregnancy drugs from steroid compounds that antagonize endometrial progesterone receptor or inhibit the synthesis of placental progesterone is an important research direction in the future.