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为探讨圆孢子虫病病理反应及临床用药情况，采用氢化可的松与环磷酰胺注射大白鼠，分别于６天、２８天灌胃接种入源型圆孢子虫卵囊［ＣＳＯ］，试建立圆孢子虫感染模型。结果白鼠在接种 ＣＳＯ３天起，粪便ＣＳＯ增加，平均在感染圆孢子虫 ＣＳＯ５天和 ７天 ＣＳＯ达高峰，白鼠均出现腹泻症状。研究表明：用氢化可的松及环磷酰胺抑制白鼠免疫后，再接种 ＣＳＯ，动物感染模型获得成功。
In order to investigate the pathogenic reaction and clinical application of Cyclosporidiosis, rats were injected with hydrocortisone and cyclophosphamide, and oocysts were inoculated intragastrically on days 6 and 28 respectively [CSO] Cyclosporidium infection model. Results The rats inoculated with CSO 3 days, stool CSO increased, with an average of 5 days in CSO infection and CSO 7 days reached a peak, the rats showed symptoms of diarrhea. Studies have shown that: hydrocortisone and cyclophosphamide inhibition of immune mice, and then inoculated with CSO animal models of infection was successful.