本文报告一例由钩端螺旋体菌苗注射引起的系统性变应性脉管炎。患者于1977年4月发病,次年3月20日入院治疗,1979年1月19日死亡,全病程642天。病理解剖发现血管炎累及皮肤、骨骼肌、肝、肺、脾、肠道等脏器。本例钩端螺旋体抗原成分可能是发病的始动因索,患者的过敏性体质是发病基础。本病早期如用大剂量皮质激素,可能治愈。 This article reports a case of systemic allergic vasculitis caused by the injection of a Leptospira bacterin. Patients in April 1977 onset, March 20 the following year admission to hospital treatment, January 19, 1979 death, the entire duration of 642 days. Pathological findings vasculitis involving the skin, skeletal muscle, liver, lung, spleen, intestine and other organs. In this case, the leptospiral antigen component may be the initiating factor, the patient’s allergic constitution is the basis of the disease. Early use of this disease, such as high-dose corticosteroids, may be cured.