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目的:通过检测脑梗死患者及正常人的血清髓鞘碱性蛋白(myelinbasicprotein,MBP)的含量,探讨脑梗死患者血清髓鞘碱性蛋白含量与脑实质损害的相关性。方法:采用双抗体夹心酶联免疫吸附法对32位正常人及30例脑梗死患者血清MBP含量进行了检测。结果:脑梗死患者和对照组血清其MBP含量分别为(5.63±3.56),(1.10±0.45)μg/L,差异有极显著性(t=7.145,P<0.001),且血清MBP含量与脑梗死体积有一定的关系。结论:脑梗死时血清MBP含量明显升高,且与脑实质损害程度有一定的关系。
Objective: To investigate the relationship between serum MBP and cerebral parenchymal damage in patients with cerebral infarction by detecting the content of serum myelin basic protein (MBP) in patients with cerebral infarction and normal subjects. Methods: Serum MBP levels in 32 normal subjects and 30 cerebral infarction patients were detected by double antibody sandwich enzyme-linked immunosorbent assay. Results: The serum levels of MBP in patients with cerebral infarction and control group were (5.63 ± 3.56) and (1.10 ± 0.45) μg / L respectively, with significant difference (t = 7.145, P <0.001) Infarct volume has a certain relationship. Conclusion: Serum MBP levels in patients with cerebral infarction are significantly increased, and have a certain relationship with the extent of brain parenchyma damage.