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选择Ⅱ级Ｗｉｓｔａｒ大鼠，随机分为三组，自妊娠第１４天开始皮下注射生理盐水、一氧化氮合成酶抑制剂亚硝基左旋精氨酸甲酯（Ｌ—ＮＡＭＥ）或Ｌ—ＮＡＭＥ联合一氧化氮供体硝普钠，直到分娩，观察抑制一氧化氮（ＮＯ）合成对孕鼠血压和重要器官的影响。结果Ｌ—ＮＡＭＥ使孕鼠血压升高、尿蛋白增加，并导致妊娠高血压综合征样的肝肾功能损害及血液变化；硝普钠可部分对抗Ｌ—ＮＡＭＥ的上述效应。提示妊娠期ＮＯ合成异常可能是导致妊娠高血压综合征发病的重要因素。
Ⅱ grade Wistar rats were randomly divided into three groups: subcutaneously injected with normal saline on the 14th day of gestation, nitric oxide synthase inhibitor L-NAME or L-NAME Nitric oxide donor sodium nitroprusside until delivery, observe the inhibition of nitric oxide (NO) synthesis of pregnant rats blood pressure and vital organs. Results L-NAME increased the blood pressure and proteinuria in pregnant rats, and led to liver and renal dysfunction and blood changes in pregnancy-induced hypertension syndrome. Sodium nitroprusside could partially antagonize the above effects of L-NAME. Tip abnormal NO synthesis during pregnancy may lead to pregnancy-induced hypertension is an important factor in the incidence.