利用 6- ( 4 -卤代苯基 ) - 3( 2 H) -哒嗪酮的银盐 ( 2 )与 2 ,3,4,6-四 - O-乙酰基 - 1 -溴 - 1 -脱氧 - α-D-吡喃葡萄糖 ( 3)发生 Koenig s- knorr反应 ,合成了 3- O- ( 2 ,3,4,6-四 - O-乙酰基 - β- D-吡喃葡萄糖 - 1 -基 ) - 6- ( 4 -卤代苯基 )哒嗪 ( 4 ) ,4用干燥的氨气在 0℃～ - 5℃下处理脱乙酰基保护基得相应的 3- O- ( β- D-吡喃葡萄糖 - 1 -基 ) - 6- ( 4 -卤代苯基 )哒嗪 ( 5 )。其结构经元素分析 ,IR及 1HNMR证实 Using silver salt (2) of 6- (4-halophenyl) -3 (2H) -pyridazinone and 2, 3,4,6-tetra-O-acetyl-1-bromo- - (2, 3,4,6-tetra-O-acetyl-β-D-glucopyranosyl-1- (4-halophenyl) pyridazine (4), 4 Treatment of the deacetylated protecting group with dry ammonia gas at 0 ° C to -5 ° C gives the corresponding 3- O- (β-D - glucopyranosyl-1-yl) - 6- (4-halophenyl) pyridazine (5). Its structure was confirmed by elemental analysis, IR and 1H NMR