连环蛋白是一组分布和作用十分广泛的细胞内糖蛋白,是细胞与细胞之间相互粘附结构的一种重要成份,磷酸化后又可作为细胞内信号传导因子和基因转录调节因子,在恶性肿瘤的发生、发展、转移和转化机制中发挥重要作用。近年来发现其与白血病细胞恶性行为密切相关。EGF、TGFa、PDGF、HGF和CSF-1等细胞因子均能使连环蛋白磷酸化,磷酸化后的连环蛋白成为白血病细胞逃避杀伤的生存信号。因此,抑制连环蛋白的磷酸化可望成为肿瘤治疗的一种新方法。 Catenin is a group of distribution and function of a wide range of intracellular glycoproteins, cells and cells is an important component of the adhesion between the structure, after phosphorylation can be used as intracellular signal transducers and gene transcription regulators in Malignant tumor occurrence, development, transfer and transformation mechanisms play an important role. In recent years, it is found that it is closely related to the malignant behavior of leukemia cells. Cytokines such as EGF, TGFa, PDGF, HGF, and CSF-1 phosphorylate catenin, and the phosphorylated catenin becomes the survival signal for leukemia cells to escape from killing. Therefore, inhibiting the phosphorylation of catenin is expected to become a new method of tumor therapy.