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白细胞介素-2(简称 IL-2)是一种重要的淋巴因子,近年来,对 IL-2的研究,包括其制备、生物学活性、分离纯化及临床应用的研究十分活跃。目前,IL-2制备除细胞培养法外,同时还建立了一系列 IL-2高产细胞系(如 MLA-144,EL-4等)以及 DNA 重组法大量制备 rIL-2(重组 IL-2),这为 IL-2的实验研究及临床应用奠定了基础。本文就 IL-2的临床应用综述如下。一、IL-2在抗肿瘤实验及临床研究中的应用IL-2在临床应用方面最引人注目的是抗肿瘤作用。肿瘤免疫中起主要作用的是细胞免疫,IL-2不
Interleukin-2 (abbreviated as IL-2) is an important lymphokine. In recent years, studies on IL-2, including its preparation, biological activity, isolation and purification, and clinical application have been very active. Currently, in addition to cell culture methods, IL-2 has also been established with a series of IL-2 high-producing cell lines (such as MLA-144, EL-4, etc.) and DNA recombinant methods for the large-scale production of rIL-2 (recombinant IL-2). This laid the foundation for the experimental research and clinical application of IL-2. This article reviews the clinical application of IL-2 as follows. First, the application of IL-2 in anti-tumor experiments and clinical research IL-2 in the clinical application of the most striking is the anti-tumor effect. The main role of tumor immunity is cellular immunity, IL-2 is not