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目的探讨妊娠期糖尿病(GDM)患者血清irisin水平与胰岛素抵抗的相关性。方法选取GDM孕妇50例为GDM组,同期正常糖耐量孕妇(NGT)50例作为NGT组。所有研究对象检测空腹血糖(FPG)、空腹胰岛素(FINS)、血清irisin水平。计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果 GDM组血清irisin水平明显低于NGT组(P<0.01)。相关分析显示GDM组血清irisin水平与FINS、HOMA-IR呈负相关(P<0.01)。结论 GDM患者血清irisin水平较正常孕妇减低,可能参与了胰岛素抵抗的发生发展。
Objective To investigate the relationship between serum irisin level and insulin resistance in patients with gestational diabetes mellitus (GDM). Methods Fifty pregnant women with GDM were selected as GDM group and 50 healthy pregnant women with normal glucose tolerance (NGT) as NGT group. All subjects tested fasting blood glucose (FPG), fasting insulin (FINS) and serum irisin levels. The homeostasis model insulin resistance index (HOMA-IR) was calculated. Results Serum irisin levels in GDM group were significantly lower than those in NGT group (P <0.01). Correlation analysis showed that serum irisin level in GDM group was negatively correlated with FINS and HOMA-IR (P <0.01). Conclusion The level of serum irisin in GDM patients is lower than that in normal pregnant women, which may be involved in the development of insulin resistance.