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目的 为观察西艾克 (VDS)采用支气管动脉灌注治疗中晚期肺癌的临床疗效及毒副反应。方法 采用经组织学及细胞学确诊的 6 3例住院中晚期肺癌经支气管动脉插管 ,用西艾克 4mg +表阿霉素 30mg +丝裂霉素 16mg或者卡铂 30 0mg ,经生理盐水稀释后导管内灌注 ,2 0～ 30天 1次 ,介入治疗前后监测周围血象及肝肾功能、胃肠道反应等。结果 6 3例共进行西艾克为主介入化疗2 46次 ,平均每例进行 3 9例次。总有效率 (CR +PR)为 5 8 7% (37/6 3) ,白细胞下降占 71 4% ,血小板下降占 2 6 9% ,恶心呕吐等胃肠道反应占 6 3 5 % ,神经系统反应占 19 0 %。但毒副反应多为Ⅰ～Ⅱ度 ,多在 1周内恢复。结论 西艾克作为一种国产新型半合成长春碱衍生物 ,经本组临床验证 ,抗癌效果确切 ,毒副作用小 ,采用支气管动脉灌注方法简便、安全 ,疗效较静脉点滴要高
Objective To observe the clinical efficacy and toxicities of bronchial arterial infusion in the treatment of advanced lung cancer with VDS. Methods Thirty-three hospitalized lung cancer patients were confirmed by histology and cytology. Bronchial arteries were cannulated with Xieike 4 mg + epirubicin 30 mg + mitomycin 16 mg or carboplatin 300 mg diluted with saline. Post-catheter infusion, 20 to 30 days, before and after interventional monitoring of peripheral blood and liver and kidney function, gastrointestinal reactions. RESULTS: Sixty-three cases were treated with interventional chemotherapy for 2 46 times, with an average of 39 cases per case. The total effective rate (CR +PR) was 58.7% (37/63), the leukopenia was 71.4%, the platelet decrease was 26.9%, and the gastrointestinal reactions such as nausea and vomiting accounted for 63.5% of the nervous system. The reaction accounted for 190%. However, the toxicities and side effects were mostly I to II degrees, and recovered in 1 week. Conclusion As a domestically-made novel semi-synthetic vinblastine derivative, Xiaike has been clinically proven to have a definite anti-cancer effect and low side effects. The bronchial arterial infusion method is simple and safe, and its efficacy is higher than intravenous drip.