茵栀四黄注射液在临床上治疗肝炎已经沿用多年,由于黄连素注射剂可引起严重的不良反应,从用药的安全性考虑研制了不含黄连素而含有黄芩甙的新茵栀四黄注射液。这种新制剂在动物实验上观察到具有更明显的退黄护肝作用。本实验通过两种制剂对豚鼠离体回肠的作用,观察到两者在药理作用及作用机制方面是有一定区别的。对肠管的自发运动虽然均表现抑制作用,但原方的作用弱,与剂量无关,新方则作用强大,并使肠平滑肌表现为剂量依赖性松弛。新方能使乙酰胆硷的量效曲线右移,接近最大反应,说明新方有抗乙酰胆硷作用。这种作用可能主要是由所含黄芩甙 Yinzhisihuang injection has been used for clinical treatment of hepatitis for many years. Since berberine injection can cause severe adverse reactions, the new Yinzhisihuang injection containing berberine without berberine has been developed from the viewpoint of drug safety. . This new preparation has been observed in animal experiments to have a more obvious effect of yellowing and hepatoprotection. In this experiment, the effects of the two preparations on isolated ileum of guinea pigs were observed, and it was observed that there was a difference between the two in pharmacological action and mechanism of action. Although all of the spontaneous movements of the intestinal tract showed inhibitory effects, the original side had a weaker effect and was not related to the dose. The new side had a strong effect and caused the intestinal smooth muscle to show a dose-dependent relaxation. Xinfang can shift the dose-response curve of acetylcholine to the right, which is close to the maximum response, indicating that Xinfang has anti-acetylcholine effect. This effect may be mainly caused by the presence of jaundice