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应用米托蒽醌（MTZ）为主的联合化疗方案，治疗成人难治性急性白血病25例，急非淋21例，急淋4例。结果完全缓解率48％，部分缓解率30％，总有效分80％。MTZ的主要毒副作用为严重的骨髓抑制及一过性肝功能损害等。结果表明：MTZ为主的联合化疗方案对于成人难治性急性白血病具和疗效高、副反应小的优点。
A combination chemotherapy regimen based on Mitoxantrone (MTZ) was used to treat 25 cases of refractory acute leukemia in adults, including 21 cases of acute non-lymphocyst and 4 cases of acute leukolysis. Results The complete remission rate was 48%, the partial remission rate was 30%, and the total effective rate was 80%. The main toxic side effects of MTZ are severe bone marrow suppression and transient liver damage. The results showed that: MTZ-based combination chemotherapy regimen for adult refractory acute leukemia with high efficacy and side effects of small advantages.