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目的:探讨孕晚期母体血浆D-二聚体检测对妊娠期高血压疾病的诊断价值。方法:抽取2018年1月至2019年12月枣庄市妇幼保健院收治的住院分娩孕妇12 442例，根据有无妊娠期高血压将其分为两组，其中有妊娠期高血压疾病者1 040例作为观察组，无妊娠期高血压疾病者11 402例作为对照组，同时将观察组分为妊娠期高血压、子痫前期、子痫三组。所有孕妇均接受孕晚期母体血浆D-二聚体检测，比较各组之间血浆D-二聚体水平，并采用受试者工作特征曲线评价孕晚期母体血浆D-二聚体对不同类型妊娠期高血压疾病的诊断价值。结果:观察组血浆D-二聚体水平为(1 523.28±100.51)μg/L，高于对照组的(1 895.20±132.16)μg/L，n P<0.05；且观察组中妊娠期高血压、子痫前期、子痫组D-二聚体水平比较差异有统计学意义，其中子痫组D-二聚体水平最高(n P<0.05)。孕晚期母体血浆D-二聚体曲线下面积在妊娠期高血压、子痫前期、子痫孕妇中分别为0.558(0.521～0.597)、0.615(0.568～0.661)、0.642(0.587～0.698)，差异有统计学意义(n P<0.05)。n 结论:对妊娠期孕妇进行孕晚期母体血浆D-二聚体检测，可为临床诊断与评估妊娠期高血压疾病提供依据，且其在妊娠期高血压、子痫前期、子痫等患者中存在差异。“,”Objective:To investigate the diagnostic value of maternal plasma D-dimer detection in the third trimester of pregnancy for hypertensive disorder complicating pregnancy.Methods:A total of 12 442 cases of hospitalized delivery pregnant women admitted to Maternal and Child Health Care of Zaozhuang from January 2018 to December 2019 were selected. And they were divided into two groups according to the occurrence of hypertension during pregnancy. Among them, 1 040 patients with hypertensive disorder complicating pregnancy were selected as the observation group, and 11 402 patients without hypertensive disorder complicating pregnancy were selected as the control group. At the same time, the observation group was divided into three subgroups: gestational hypertension group, preeclampsia group, and eclampsia group. All pregnant women received maternal plasma D-dimer detection in the third trimester of pregnancy, and the differences of plasma D-dimer levels among the groups were compared. The diagnostic value of maternal plasma D-dimer in different types of hypertensive disorder complicating pregnancy was evaluated by receiver operating characteristic curve.Results:The plasma D-dimer level of the observation group was (1 523.28 ± 100.51)μg/L, which was higher than the (1 895.20 ± 132.16)μg/L of the control group (n P<0.05). In the observation group, there were significant differences in D-dimer levels among gestational hypertension group, preeclampsia group, and eclampsia group, and the D-dimer level in eclampsia group was the highest (n P<0.05). The area under curve of the plasma D-dimer in the third trimester of pregnancy was 0.558 (0.521-0.597), 0.615 (0.568-0.661) and 0.642 (0.587-0.698) in pregnancy-induced hypertension, preeclampsia, and eclampsia, respectively, and the difference was significant (n P<0.05).n Conclusions:The detection of maternal plasma D-dimer in pregnant women during the third trimester can provide the basis for clinical diagnosis and evaluation of hypertensive disorder complicating pregnancy, and it can also be used for the types of hypertension, preeclampsia, eclampsia and so on. The D-dimer levels in patients with gestational hypertension, preeclampsia, eclampsia were different.