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重症再生障碍性贫血(下简称再障)是病毒性肝炎(下简称肝炎)的罕见而重要的并发症;但致病因子尚不明确。1975~1981年,美国 UCLA 医学研究中心收治149名重症再障病人中,20例系肝炎并发再障,均未接触过损害肝脏和骨髓的毒物;19例血清 HBsAg 阴性,取其中16例为研究组。随机取10例重症再障为对照组,再障发生前无肝炎或接触血液制品的历史。血清谷-丙转氮酶、谷—草转氨酶,血胆红质、AKB 均正常。26例入院前均接受过10单位以上的血液制品治疗。
Severe aplastic anemia (hereinafter referred to as aplastic anemia) is a rare and important complication of viral hepatitis (hereinafter referred to as hepatitis); but the pathogenic factor is not yet clear. From 1975 to 1981, among the 149 patients with severe aplastic anemia who were treated in the UCLA Medical Research Center in the United States of America, 20 were complicated by aplastic anemia. None of them had been exposed to toxic agents that damaged the liver and bone marrow. Of the 19 patients, 16 were negative for HBsAg, group. Ten cases of severe aplastic anemia were randomly selected as the control group. There was no history of hepatitis or blood products before aplastic anemia. Serum Valley - CZA, Valley - grass transaminase, blood bilirubin, AKB were normal. All 26 patients received more than 10 units of blood products before admission.