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目的 :家犬口服FDP钙盐 2g kg或静脉输注 10 0、2 0 0mg kg(速率 2mL min、4mL min)观察其吸收情况及药物动力学参数。方法 :用Michal和Beutler氏酶法检测血浆FDP浓度 ,用CAPP软件确定模型和拟合C_T曲线。结果 :c_t曲线为二室开放模型 ,静脉输注药动学参数分别为 :β(min-1) 0 .113± 0 .0 76和 0 .118± 0 .0 55;t1 2 β(min) 6 .6 2± 2 .95和 6 .96± 3.0 3;Tmax(min) 1.4 6± 0 .4 6和 1.90± 0 .2 9;Cmax(μg mL) 144 .6 2± 94 .58和 2 52 .4 6± 73.2 1;AUC(mg L·min-1) 781.4 7± 2 81.97和 1974 .11± 797.2 1。Cmax和AUC是随剂量增大而增大 ,其余参数两种剂量间无显著性差异 (P >0 .0 5)。口服FDP钙盐胃肠道吸收有限 ,本文对其原因作了探讨。
OBJECTIVE: To observe the absorption and pharmacokinetic parameters of dogs with oral FDP calcium 2 g kg or intravenous infusion of 10,200 mg kg (2 mL min, 4 mL min). Methods: Plasma FDP concentrations were measured by Michal and Beutler’s enzymatic methods. The CAPP software was used to determine the model and fit the C_T curve. Results: The curve of c_t was a two-compartment open model. The parameters of pharmacokinetics of intravenous infusion were β (min-1) 0.113 ± 0.76 and 0.118 ± 0.055, t1 2 β (min) 6 .6 2 ± 2 .95 and 6 .96 ± 3.0 3; Tmax (min) 1.4 6 ± 0.46 and 1.90 ± 0.29; Cmax (μg mL) 144 .62 ± 94 .58 and 2 52.4 ± 73.2 1; AUC (mg L · min-1) 781.4 7 ± 2 81.97 and 1974 .11 ± 797.2 1. Cmax and AUC increased with dose, while the other parameters had no significant difference between the two doses (P> 0.05). Oral FDP calcium gastrointestinal absorption is limited, the paper discussed its causes.