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Aim To synthesize six kinds of compounds carrying halogen and trifluoromethyl and confirm their structures,and test their antifungi activities simultaneously.Method With 2-halogen resorcinol and beta ketone ester as raw materials,conducting in strong acid medium by Pechmann condensation reaction,then their products were mixed with different RCl by Williamson reaction to get target molecules.Their structures were confirmed by 1H NMR and MS spectrums,and the antibacterial activities were tested by the growth rate method.Results Six kinds of compounds carrying halogen and trifluoromethyl were synthesized and characterized,and their antifungi activities were tested,as well as the relationship between structures and antibacterial effects were speculated.Conclusion Six coumarin compounds have been prepared,and their structures were confirmed.The antibacterial test shows that compounds 2a～2d have strong activities against Fusarium graminearum Schw.The existence of 7-OH enabled the antibacterial activity enhancing,and 7-OH is the active group.
Aim To synthesize six kinds of compounds carrying halogen and trifluoromethyl and confirm their structures, and test their antifungi activities simultaneously. Method with 2-halogen resorcinol and beta ketone ester as raw materials, conducting in strong acid medium by Pechmann condensation reaction, then their products were mixed with different RCl by Williamson reaction to get target molecules. Their structures were confirmed by 1H NMR and MS spectrums, and the antibacterial activities were tested by the growth rate method. Results Six kinds of compounds carrying halogen and trifluoromethyl were synthesized and characterized, and their antifungi activities were tested, as well as the relationship between structures and antibacterial effects were speculated. Confirmation Six coumarin compounds have been prepared, and their structures were confirmed. antibacterial test shows that compounds 2a ~ 2d have strong activities against Fusarium graminearum Schw The existence of 7-OH enabled the antibacte rial activity enhancing, and 7-OH is the active group.