前瞻性流行病学研究资料提示了慢性HBsAg携带者发生原发性肝癌(HCC)的相对危险性比非携带者高200倍。应用Southern分子杂交法也证实HCC癌组织与肝癌细胞株中含有整合的HBVDNA。这些研究结果表明HBV慢性感染与HCC发病之间的密切联系。但HBV基因及基因产物 Prospective epidemiological studies suggest that the relative risk of developing primary liver cancer (HCC) in chronic HBsAg carriers is 200-fold higher than in non-carriers. The use of Southern molecular hybridization also confirmed the integration of HBV DNA in HCC and HCC cell lines. These findings suggest a close link between chronic HBV infection and the onset of HCC. But HBV gene and gene product