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能致药源性狼疮(DRL)的药物可被分成3组:(1)明确有关,(2)可能有关,(3)无关或关系尚未证实。四环素类(包括米诺环素)属于第3组。此外,四环素可能是一种狼疮刺激/恶化剂,而非诱导剂。本文报道了1例病人,在始用米诺环素(minocycline)2年后,突然发生了狼疮样综合征。患者为22岁的日本妇女,因发热、干咳和全身关节痛而就诊。入院前2年,患者一直使用100～150mg/d的米诺环素以治疗其脸部痤疮。无严重疾病、脱发或光敏反应史。无白细胞减少和血小板减少史。家族史亦无异
Drugs that cause drug-induced lupus (DRL) can be divided into three groups: (1) specific, (2) potentially relevant, (3) unrelated, or not yet confirmed. Tetracyclines (including minocycline) belong to the third group. In addition, tetracycline may be a lupus irritant / exacerbant rather than an inducer. This article reports one patient who developed lupus-like syndrome suddenly 2 years after starting minocycline. A 22-year-old Japanese woman was treated for fever, dry cough and generalized joint pain. 2 years before admission, patients have been using 100 ~ 150mg / d of minocycline to treat facial acne. No serious illness, hair loss or a history of photosensitive reactions. No history of leukopenia and thrombocytopenia. Family history is no different