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目的:对传统秘方“康瑞痛风胶囊”治疗痛风进行药效学研究。方法:建立镇痛实验和抗炎实验动物模型,分组进行实验研究。结果:通过实验研究发现康瑞痛风胶囊具有升高小鼠痛阈值、抑制酒石酸锑钾引起的小鼠扭体反应、降低二甲苯致小鼠耳肿胀程度、减轻棉球肉芽肿的重量、抑制MSUC致大鼠脚肿胀、减轻MSUC致大鼠步态分级级数的作用。结论:康瑞痛风胶囊具有良好的镇痛、抗炎效果。
Objective: To study the pharmacodynamics of the traditional recipe “Kangru gout capsule” in the treatment of gout. Methods: Analgesic and anti-inflammatory experimental animal models were established and divided into groups for experimental study. Results: It is found through experimental study that Kangru Gout Capsule can increase writhing threshold of mice, inhibit the writhing reaction of mice caused by antimony potassium tartrate, reduce the ear swelling of mice caused by xylene, relieve the weight of cotton ball granuloma and inhibit MSUC Causing swelling of rat’s feet, reducing the effect of MSUC-induced rat gait grading series. Conclusion: Kangru gout capsule has good analgesic and anti-inflammatory effects.