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目的分析临床机采血小板输注无效(PTR)的原因,为临床科学、合理、有效使用血小板提供参考依据和对策。方法 47例(172例次)输注机采血小板患者,按疾病分组:血液肿瘤病27例,外科手术13例,其他疾病7例。按输注频率分组:输注1~3次为低频组36例,输注≥5次为高频组11例。计算血小板校正增加指数(CCI)来判断临床疗效。结果外科手术及其他疾病患者输注血小板无效率明显低于血液肿瘤病患者,差异有统计学意义(P<0.05)。低频组血小板输注有效率46.6%高于高频组的23.8%,差异有统计学意义(P<0.05)。结论血小板输注疗效受很多因素影响。若输注频率增加,有效率就会逐渐下降,很容易出现血小板抗体,继而PTR,临床应进行配合型血小板输注。
Objective To analyze the causes of clinical failure of platelet transfusion (PTR) and provide references and countermeasures for clinical use of platelets in a rational and effective manner. Methods Totally 47 cases (172 cases) received platelet transfusion machine. According to the disease group, there were 27 cases of hematological tumor, 13 cases of surgical operation and 7 cases of other diseases. According to the frequency of infusion groups: 1 to 3 times infusion for the low-frequency group of 36 cases, 5 times for the high-frequency group of 11 patients. Calculate the platelet increase correction index (CCI) to determine the clinical efficacy. Results In patients with surgical and other diseases, the inefficacy of transfusion of platelets was significantly lower than that of patients with hematological tumors (P <0.05). The effective rate of platelet transfusion in low frequency group was 46.6% higher than that in high frequency group (23.8%), the difference was statistically significant (P <0.05). Conclusion Platelet transfusion is affected by many factors. If the infusion rate increases, the efficiency will gradually decline, it is easy to platelet antibodies, then PTR, clinical should be combined with platelet transfusion.