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目的研究ＥＧＦ受体（ＥＧＦＲ）在大肠癌中表达的意义，并探讨其对细胞增殖的影响．方法用免疫组化ＬＳＡＢ法检测８６例大肠癌组织ＥＧＦＲ，ＰＣＮＡ的表达．结果在８６例被检组织中，ＥＧＦＲ阳性表达４４例（５１２％），低分化癌（８００％，４０／５０）、淋巴结转移癌（６８８％，２２／３２）较高分化（３８９％，１４／３６）、淋巴结未受累大肠癌（４０７％，２２／５４）有更高的ＥＧＦＲ表达（Ｐ＜００５）．ＤｕｋｅｓＡ，Ｂ，Ｃ期大肠癌的ＥＧＦＲ表达率分别为３２０％，４８３％，６８８％，Ｃ期与Ａ期比较差异显著；ＥＧＦＲ阳性大肠癌较阴性癌有更高的ＰＣＮＡ标记（两者ＰＣＮＡⅠ，Ⅱ，Ⅲ，Ⅳ级的例数分别为４，８，１７，１５；１４，１６，７，５；Ｐ＜００５）．结论ＥＧＦＲ过表达与大肠癌恶性程度、转移趋势密切相关，并可促使癌细胞过度增生．
Objective To study the significance of EGF receptor (EGFR) expression in colorectal cancer and to explore its effect on cell proliferation. Methods The expression of EGFR and PCNA in 86 cases of colorectal cancer tissue was detected by immunohistochemistry LSAB method. Results Of the 86 tissues examined, 44 were positive for EGFR (51. 2%), poorly differentiated (80.0%, 40/50), and metastatic lymph nodes (68.8%, 22/32). Differentiation (38.9%, 14/36), lymph node-insensitive colorectal cancer (40.7%, 22/54) had higher EGFR expression (P < 0.05). The expression of EGFR in Dukes A, B, and C colorectal cancers was 32.0%, 48.4%, 68.8%, respectively. There was significant difference between C and A phase. EGFR positive colorectal cancer had higher PCNA than negative cancer. Markers (the number of PCNAI, II, III, IV grades were 4, 8, 17, 15, 14, 16, 7, 5; P<005). Conclusion Overexpression of EGFR is closely related to the degree of malignancy and metastasis of colorectal cancer, and can promote the hyperplasia of cancer cells.