早期的研究表明,雌激素疗法不但可增加心肌梗塞男性幸存者再发心肌梗塞的危险性,而且还可增加前列腺癌患者的心血管病病死率。此后在一系列的观察中,亦发现在急性心肌梗塞的幸存者、临床证明有冠心病的患者和经冠状动脉造影证实有冠状动脉病变的患者,雌激素水平均呈增高。作者在一项病例对照研究中,亦证实急性心肌梗塞男性患者的雌二醇水平增高。上述一系列研究结果提示,雌二醇水平增高可能会成为冠状动脉病的一种标志,或怍为有发生冠状动脉病的一种危险因素。为了有助于阐明这些问题, Early studies showed that estrogen therapy not only increased the risk of recurrent myocardial infarction in male survivors with myocardial infarction but also increased cardiovascular mortality in patients with prostate cancer. Since then, in a series of observations, it has also been found that estrogen levels are elevated in survivors of acute myocardial infarction, patients with clinically proven coronary heart disease, and patients with coronary artery lesions confirmed by coronary angiography. In a case-control study, the authors also demonstrated elevated estrogen levels in men with acute myocardial infarction. The above series of findings suggest that elevated estradiol levels may be a hallmark of coronary artery disease or a risk factor for coronary artery disease. To help clarify these issues,