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人应用皮质类固醇(CRS)后,发现淋巴细胞极度减少,这与CRS溶解淋巴细胞无关,而是CRS改变淋巴细胞运行的结果。最近证明T细胞群从血管内游出比其它免疫活性细胞明显。带有IgG Fc受体的T细胞对GRS不敏感;而带有IgM Fc受体的T细胞对CRS敏感。本文用单克隆抗体分析了一次口服剂量的强的松对T淋巴细胞亚群的影响。6名健康人(20—43岁)在服药前和一次口服12mg强的松后4、6、8、24、72小时取血,应用连续血浆凝胶沉淀法和聚蔗
After the application of corticosteroid (CRS), people found that lymphocytes are extremely reduced, which is not related to the CRS lytic lymphocytes, but the result of CRS changing lymphocyte operation. Recently it has been demonstrated that T-cell populations travel significantly from the blood vessels more than other immunocompetent cells. T cells with IgG Fc receptors are not GRS-sensitive; T cells with IgM Fc receptors are CRS-sensitive. In this paper, monoclonal antibody analysis of an oral dose of prednisone on T lymphocyte subsets. Six healthy individuals (20-43 years old) were bled 4, 6, 8, 24 and 72 hours prior to taking the medication and 12 mg of prednisone after oral administration, using continuous plasma gel precipitation and polysaccharides