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本文采用Pr(dpm)_3诱导CD裂分Cotton效应法、激子手性法和Horeau法对新缩瞳剂包公藤甲素(1)及其类似物包公藤丙素(2)、凹脉丁公藤碱(3)及两者的N-甲基化物(4、5)进行了研究。确定了它们的绝对构型分别为:(2S,6S)2β-羟基-6β-乙酰氧基去甲莨菪烷、(2S,6S)-2β,-6β-二羟基去甲莨菪烷、(2S,7R)-2β,7β-二羟基去甲莨菪烷、(2S,6S)-2β,6β-二羟基莨菪烷和(2S,7R)-2β,7β-二羟基莨菪烷。通过构象分析和用绝对构型已知的化合物验证,初步解释了Horeau法的测定结果。
In this paper, Pr (dpm) _3 inducing CD split Cotton effect method, exciton chiral method and Horeau method for the new miotic agent kirtuin (1) and its analogs of kudzu promethazine (2) The base (3) and the N-methide (4,5) of both were investigated. Their absolute configurations were confirmed to be (2S, 6S) 2β-hydroxy-6β-acetoxynotetane, (2S, 6S) -2β, -6β-dihydroxynorotane, (2S, 7R) -2β, 7β-dihydroxynitropane, (2S, 6S) -2β, 6β-dihydroxytodane and (2S, 7R) -2β, 7β-dihydroxypicotine. Through the conformational analysis and verification of compounds known in absolute configuration, the results of the Horeau assay are initially explained.