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我们曾研究过山莨菪碱(654)的药理作用,并发现它在临床上有确实而起效快的祛痰作用。但有的报道认为,用小鼠酚红法和大鼠毛细管法试验,它本身并无祛痰作用。为探讨山莨菪碱的祛痰作用机理,本文进行如下试验。 方法和结果 一、小鸡气管上皮细胞纤毛运动的观察 1.正常纤毛运动:小鸡腹腔注射乌拉坦(1mg/kg)与戊巴比妥钠15mg/kg麻醉,暴露气管,在无热光源照明下,从气管壁上方,注入印度墨汁6微升,观察静注山莨菪碱10mg/kg前后墨汁向头端的运动速
We have studied the pharmacological action of anisodamine (654) and found that it has a clinically proven and rapid expectorant effect. However, some reports suggest that there is no expectorant effect by the mouse phenol red method and the rat capillary test. In order to explore the mechanism of anisodamine’s expectorant effect, this paper carries on the following experiment. Methods and Results (1) Observation of cilia movement of chicken tracheal epithelial cells 1. Normal cilia movement: Chickens were anesthetized with urethane (1mg / kg) and sodium pentobarbital 15mg / kg intraperitoneally to expose the trachea. , From the top of the trachea, the Indian ink was injected into 6 microliters to observe the movement of the ink toward the tip before and after intravenous injection of anisodamine 10 mg / kg