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[目的]通过检测胃癌高、低发区健康居民血清中的微量元素含量,探讨微量元素与胃癌的关系。[方法]随机抽取高、低发区年龄在50～65岁范围的常住健康居民,高发区206人,低发区102人,抽取静脉血5ml分离出血清,采用等离子体质谱法(ICP-MS)和原子荧光光谱法(AFS)检测镉(Cd)、锰(Mn)、钼(Mo)、汞(Hg)等16种微量元素,对数据进行非参数秩和检验。[结果]高发区健康居民血清中As、Ba、Cr、Hg、Li、Se、Fe、Zn8种元素高于低发区,差异有统计学意义(P﹤0.05);而Mo、Cd元素含量低于胃癌低发区,差异有统计学意义(P﹤0.05)。Co、Mn、Ni、Pb、Sr、Cu在两地健康居民血清中差异无统计学意义。[结论]胃癌高、低发区健康居民体内的微量元素负荷存在差异,钼、铁、铜、锌等元素可能与胃癌的发生有一定的关系。
[Objective] To explore the relationship between trace elements and gastric cancer by detecting the content of trace elements in serum of health residents with high and low incidence of gastric cancer. [Methods] The resident healthy residents aged 50-65 years in high and low incidence areas were randomly selected. The high incidence area was 206 and the low incidence area was 102. Serum was extracted from 5 ml of venous blood and analyzed by ICP-MS ) And atomic fluorescence spectrometry (AFS) were used to detect 16 kinds of trace elements such as Cd, Mn, Mo and Hg. The data were tested by nonparametric rank sum test. [Result] The contents of As, Ba, Cr, Hg, Li, Se, Fe and Zn in serum of healthy residents in high incidence areas were higher than those in low incidence areas, the difference was statistically significant (P <0.05) In the low incidence of gastric cancer, the difference was statistically significant (P <0.05). Co, Mn, Ni, Pb, Sr and Cu had no significant difference in the serum of healthy residents between the two places. [Conclusion] The microelements load of healthy residents in high and low incidence area of gastric cancer are different. The elements such as molybdenum, iron, copper and zinc may have a certain relationship with the occurrence of gastric cancer.