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目的:观察大黄分别与甘草、炙甘草、黄连配伍后,以及在复方制剂泻心汤中大黄对大鼠的肝肾毒性,为临床合理应用大黄提供依据。方法 :各配伍组制备总提取物,以大黄生药量计,按18g/kg(大黄生药)灌胃,每天给药1次,连续30天。结果:大鼠在给药大黄总提物18g/kg(大黄生药)两周后就表现出一定肝肾毒性,生化指标ALT、AST、CR呈不同程度地升高。并且给药30天后ALT、AST、CR不同程度地升高,BUN略降低,肝脏有轻度嗜酸性病变及轻度水肿,肾脏出现轻度淤血、水肿和核固缩。除炙甘草外,大黄与甘草、黄连配伍后及在泻心汤中均显示大黄肝肾毒性有所降低。结论:大黄配伍后在一定程度上减轻其肝肾毒性。
OBJECTIVE: To observe the hepatotoxicity of rhubarb on the rats after combination of rhubarb with licorice, Zhigancao, Coptis chinensis and rhubarb in the compound preparation Xiexin Tang, so as to provide the basis for clinical application of rhubarb. Methods: The total composition of the preparation of the compatibility group, the rhubarb raw dosimeters, according to 18g / kg (rhubarb crude drug) gavage once daily for 30 days. Results: The rats showed some hepatorenal toxicity after administration of 18g / kg rhubarb extract (rhubarb crude drug) for two weeks. The biochemical indexes ALT, AST and CR increased to some extent. ALT, AST and CR increased to some extent after 30 days of administration, with a slight decrease of BUN, mild eosinophilic lesion and mild edema in the liver, mild congestion, edema and nuclear pyknosis in the kidneys. In addition to Zhigancao, rhubarb and licorice, Coptis compatibility and in the Xiexin Tang showed yellow rhubarb and kidney toxicity decreased. Conclusion: rhubarb compatibility to a certain extent, reduce the liver and kidney toxicity.