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目的:对肺癌患者进行七项血清学指标观察,探讨其在肺癌病程发展及治疗过程中的临床意义.方法:采用ELISA、IRMA和RIA法对肺癌组(273例)、慢性支气管炎组(179例)、正常对照组(193例)进行血清LN、sE-SLT、HA、CA242、NSE、CEA、AIF含量测定.统计学处理两组均数差别显著性分析采用t检验.结果:肺癌患者七项指标与正常对照组比较含量相差非常显著(P<0.01),而与慢性支气管炎比较LN、sE-SLT含量无显著性差异(P>0.05),HA、CEA、CA242、NSE、AIF含量明显升高(P<0.01).结论:上述结果提示LN和sE-SLT对于肺癌和慢性支气管炎的鉴别诊断无特异性,但与病情变化密切相关;HA、CEA、CA242、NSE、AIF则对于两种疾病的鉴别诊断具有一定参考价值,多项指标的联合检测对于肺癌的诊断、病情观察、判定疗效及预后有重要临床意义.
Objective: To observe seven serological indicators of lung cancer patients and explore its clinical significance in the development and treatment of lung cancer. Methods: ELISA, IRMA and RIA for lung cancer group (273 cases), chronic bronchitis group (179) In the normal control group (193 cases), serum LN, sE-SLT, HA, CA242, NSE, CEA, and AIF levels were measured. Statistical analysis was used to analyze the significance of the differences between the two groups using t-test. Results: Lung cancer patient seven The difference between the index and the normal control group was very significant (P<0.01), but there was no significant difference in the content of LN and sE-SLT compared with chronic bronchitis (P>0.05). The contents of HA, CEA, CA242, NSE, and AIF were significant. Increased (P<0.01). Conclusions: These results suggest that LN and sE-SLT are not specific for the differential diagnosis of lung cancer and chronic bronchitis, but are closely related to the change of condition; HA, CEA, CA242, NSE, and AIF are both The differential diagnosis of the disease has a certain reference value. The joint detection of multiple indicators has important clinical significance for the diagnosis of lung cancer, observation of the condition, determination of efficacy and prognosis.