氨基糖苷类抗生素(简称氨基糖苷类)是细菌蛋白合成的强力抑制剂,它能使细菌核糖体分解。由于一系列氨基酸的异常排列和菌体表面蛋白的不可逆结合,可发生遗传密码错读现象。此外,氨基糖苷类的杀菌作用与菌体细胞呼吸和胞浆膜通透性障碍以及DNA的稳定性破坏等有关。 Aminoglycoside antibiotics (aminoglycosides) are potent inhibitors of bacterial protein synthesis that break down bacterial ribosomes. Due to the abnormal arrangement of a series of amino acids and the irreversible binding of cell surface proteins, misreading of the genetic code can occur. In addition, the role of aminoglycoside bactericidal and bacterial cell respiration and cytoplasmic membrane permeability barriers and the stability of DNA damage and so on.