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作者检查了3例乙型肝炎病毒(HBV)感染患者脾组织中的病毒复制。这3例慢性乙型肝炎患者的血清转氨酶活性、HBsAg、HBeAg、HBV DNA和DNA聚合酶持续升高。患者1:男性,61岁,组织学检查证实有肝硬变,死于肝衰竭。患者2:男性,32岁,经由同性恋感染HBV,人免疫缺陷病毒抗体血清学也为阳性。2年前肝活检证实有轻度慢性活动性肝炎。患者3:男性,58岁,由于针刺损伤感染HBV,死于自发性细菌性腹膜炎,肝的组织学检查证实有肝硬变。采肝和脾组织,提取DNA。用缝隙印
The authors examined the viral replication in 3 spleen tissues from patients with hepatitis B virus (HBV) infection. Serum aminotransferase activity, HBsAg, HBeAg, HBV DNA and DNA polymerase in these 3 patients with chronic hepatitis B continued to increase. Patient 1: Male, age 61, histologically confirmed cirrhosis, died of liver failure. Patient 2: Male, 32 years old, infected with HBV via homosexuality, human immunodeficiency virus antibody seropositivity was also positive. Two years ago liver biopsy confirmed mild chronic active hepatitis. Patient 3: Male, 58 years old, died of spontaneous bacterial peritonitis due to acupuncture damage to HBV and liver histology confirmed cirrhosis. Liver and spleen tissue, DNA extraction. With slit printing